Encyclopedia · surfactant
Sodium cocoyl glutamate
An amino-acid-based cleanser that was among the best-tolerated surfactants in a 105-patient patch-test study, with no scalp or hair trials yet.
What it is
Sodium cocoyl glutamate is formed from coconut fatty acids and glutamic acid. It is a mild anionic with gentle foam, used in sulfate-free shampoos and facial cleansers.
How it works
It forms anionic micelles with low skin interaction. Mixed with SLS, it reduced SLS irritation in volunteers, although that study used the related sodium lauroyl glutamate (Lee 1994).
What the studies show
- In 105 patients patch-tested with eight cleansing surfactants, none caused irritation or allergic reactions at the tested dilution. The best tolerated were sodium cocoyl glutamate, sodium lauroyl oat amino acids and disodium cocoamphodiacetate, while cocamidopropyl betaine from the standard series gave 5 positives (Corazza 2010).
- In 15 volunteers with randomized skin sites, a glutamate surfactant was much less irritating than SLS, and mixing it with SLS reduced SLS irritation (Lee 1994).
- A review gives an overview of shampoo surfactant raw materials and the trend toward sulfate-free systems (Cornwell 2018).
Skin tolerance data from human patch tests are good, while hair and scalp performance data are absent.
Side effects and safety
Irritation and allergy rates were low in the 105-patient study, and we found few allergy reports.
Bottom line
One of the better evidence-backed mild cleansers for sensitive scalps and for dry, curly hair. Expect lighter lather and gentler cleansing than a sulfate shampoo. No head-to-head scalp or hair-feel trials were found.
Studies 3
Corazza M et al. Irritant and sensitizing potential of eight surfactants commonly used in skin cleansers: an evaluation of 105 patients. Dermatitis. 2010
Tested: eight cleansing surfactants
Result: None caused irritation at the tested dilution; best tolerated were sodium cocoyl glutamate, sodium lauroyl oat amino acids and disodium cocoamphodiacetate.
Read the study ↗Lee CH, Kawasaki Y, Maibach HI. Effect of surfactant mixtures on irritant contact dermatitis potential in man: sodium lauroyl glutamate and sodium lauryl sulphate. Contact Dermatitis. 1994
Tested: sodium lauroyl glutamate, SLS, and mixtures
Result: Sodium lauroyl glutamate was much less irritating than SLS, and mixing it into SLS reduced SLS irritation.
Read the study ↗Cornwell PA. A review of shampoo surfactant technology: consumer benefits, raw materials and recent developments. Int J Cosmet Sci. 2018
Result: Overview of shampoo surfactant raw materials, consumer benefits and trends in sulfate-free systems.
Read the study ↗Related
- Sodium cocoyl glycinateA glycine-based mild cleanser with one industry body-wash study showing mildness and no scalp or hair studies.
- Sodium lauroyl sarcosinateAn amino-acid-derived cleanser with good foam and cleaning power that is marketed as mild, though its mildness sits in the middle.
- Sodium cocoyl isethionateA mild anionic cleanser, the basis of many syndet bars, with good lab evidence of being gentle on the skin barrier and growing use in sulfate-free shampoos and shampoo bars.
- Decyl glucosideA plant-derived mild cleanser marketed as ultra-gentle, but its best-documented concern is a rising rate of contact allergy.