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Hair dye and smoothers: what to check first

2 min read6 steps7 studies

In short

Patch test every colour. Black henna tattoos are the biggest known route to dye allergy. 'Ammonia-free' colour was not gentler in a lab test, and 'formaldehyde-free' smoothers can still release formaldehyde. Hair dye did not raise bladder-cancer risk.

Do this

  1. 1

    Patch test every colour before each use, following the timing on the box.

  2. 2
    Skip black henna tattoos.Why

    Black henna is red henna plus the dye PPD.

  3. 3

    Pick colour by lift and past damage, not by the word 'ammonia-free'.

  4. 4

    Ask for a smoother's full ingredient list; avoid glyoxylic acid, linked to kidney injury.

  5. 5

    What the science points to: ventilating during smoothing likely lowers fume exposure.

  6. 6

    Itching, swelling or blisters after colour or smoother? Stop and talk to a doctor.

The numbers behind it

  • 85%

    More damage in the most extreme case, monoethanolamine colour against ammonia colour, in a hair-colour maker's lab.

  • 9.3x

    Higher odds of PPD allergy after a black henna tattoo, among 10,425 Europeans (3.2% against 0.6%).

  • 4 of 4

    Smoothers tested gave off formaldehyde or formaldehyde-forming compounds, including ones labelled formaldehyde-free.

  • 1.64x

    Higher uterine cancer risk after menopause with heavy relaxer use, in 44,798 Black women followed 1997 to 2019.

For your hair

  • Box dye at home

    Patch test every time. In the European study, black henna was the main risk factor, not hair dye use itself.

  • Teens and parents

    A holiday black henna tattoo is an easy route to dye allergy. Sensitised children may react to hair dyes later.

  • Bleached or already coloured hair

    Each round adds damage. Stretch the gaps between colours and between chemical treatments.

  • Relaxers and keratin smoothers

    Formaldehyde peaked during blow-drying in the salon test, so choose a ventilated room. Space out relaxers; long use went with uterine cancer after menopause.

Myths to ignore

  • Myth Ammonia-free colour is gentler on hair.

    Truth In a lab comparison, monoethanolamine colour damaged hair more than ammonia colour on every measure, up to 85% more. Ammonia-free mostly means less smell.

    Bailey 2014 ↗
  • Myth Black henna is just darker natural henna.

    Truth Black henna is red henna plus PPD, a strong sensitiser. About 1 in 40 people tattooed with it become allergic and can then react to hair dyes.

    de 2013 ↗
  • Myth 'Formaldehyde-free' smoothers contain no formaldehyde.

    Truth Smoothers labelled formaldehyde-free still gave off formaldehyde or compounds that turn into it when heated, at levels that could reach workplace limits.

    Pierce 2011 ↗
  • Myth Hair dye causes bladder cancer.

    Truth Pooling 17 studies gave a relative risk of 0.93 for personal hair dye use, and no extra risk even with the longest use.

    Turati 2014 ↗

Go deeper

All studies in this guide (7)

Bailey AD et al. Comparison of damage to human hair fibers caused by MEA- and ammonia-based hair colorants. J Cosmet Sci. 2014

Who
human hair, Procter & Gamble laboratory

Tested: monoethanolamine versus ammonia colourants

Result: Colourants with monoethanolamine caused up to 85% more damage than ammonia-based ones.

Read the study ↗

Diepgen TL et al. Prevalence of Contact Allergy to p-Phenylenediamine in the European General Population. J Invest Dermatol. 2016

People
10,425
Who
general population of 5 European countries; 10,425 interviewed, 2,739 patch tested

Tested: interview on hair dye and black henna tattoo use, plus a patch test to p-phenylenediamine (PPD)

Result: 0.8% had a contact allergy to PPD. It was 3.2% in people who had ever had a black henna tattoo against 0.6% in those who had not, an adjusted odds ratio of 9.33. Only 0.1% had a PPD reaction clearly tied to hair colour products.

Read the study ↗

de Groot AC. Side-effects of henna and semi-permanent 'black henna' tattoos: a full review. Contact Dermatitis. 2013

Design
review

Result: Black henna contains PPD and sensitises about 2.5% of people after a tattoo; red henna rarely causes allergy but can cause haemolysis in children with G6PD deficiency.

Read the study ↗

Turati F et al. Personal hair dye use and bladder cancer: a meta-analysis. Ann Epidemiol. 2014

Design
meta analysis
People
17
Who
17 studies

Tested: personal hair dye use

Result: Pooled bladder-cancer risk RR 0.93.

Read the study ↗

Pierce JS et al. Characterization of formaldehyde exposure resulting from the use of four professional hair straightening products. J Occup Environ Hyg. 2011

Who
four professional hair straightening products

Result: Bulk formaldehyde ranged from 0% to 11.5% by weight, and even products labelled formaldehyde-free could meet or exceed occupational limits.

Read the study ↗

Robert T et al. Hair-straightening cosmetics containing glyoxylic acid induce crystalline nephropathy. Kidney Int. 2024

Who
one patient with kidney injury plus mice

Tested: glyoxylic acid hair straightener exposure

Result: Glyoxylic acid straightener use was linked to crystal-forming kidney damage in a patient, and the damage was reproduced in mice.

Read the study ↗

Bertrand KA et al. Hair relaxer use and risk of uterine cancer in the Black Women's Health Study. Environ Res. 2023

Design
cohort
People
44,798
Who
Black women in the Black Women's Health Study

Tested: hair relaxer use

Result: No overall increase for heavy use (HR 1.18, CI 0.81-1.71), but higher risk in postmenopausal women (HR about 1.6-1.7).

Read the study ↗